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In the SKYLIGHT 1 trial, which included 522 women, fezolinetant demonstrated efficacy in reducing hot flashes in menopausal and perimenopausal women, with a 58% and 61% decrease at a dosage of 30 mg and 45 mg, respectively, after 12 weeks of treatment

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Similarly, studies on Danzhi-Xiaoyao-San indicate that it exerts an antidepressant effect by modulating the composition of the gut microbiota in patients with depression and influencing metabolic pathways [600]

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